Firazyr (Icatibant) Injection

Firazyr injection is used to treat sudden attacks of hereditary angioedema (HAE). Firazyr works by blocking a chemical in the body that causes swelling, inflammation, and pain for patients with HAE

Uses Of Firazyr Injection

• Hereditary Angioedema (HAE)

Benefits Of Firazyr Injection 

In Hereditary Angioedema (HAE)

Firazyr is a bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE).

Side Effects Of Firazyr Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Firazyr 

• Fever
• Dizziness
• Headache
• Nausea
• Rash
• Bleeding
• Blistering
• Burning
• Coldness
• Discoloration of the skin
• Feeling of pressure
• Hives
• Infection
• inflammation
• Itching
• Lumps
• Numbness
• Pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration

How To Use Firazyr Injection

A nurse or other trained health professional will give you this medicine in a hospital or emergency clinic. This medicine is given as a shot under your skin, usually in the abdomen or stomach.

How Firazyr Injection Works

Firazyr is a bradykinin B2 receptor which is a peptide-based hormone that is formed locally in tissues in response to a trauma and acts to increases vessel permeability, dilates blood vessels and causes smooth muscle cells to contract. Bradykinin plays an important role in the mediation of pain as surplus bradykinin is partly responsible for producing signs of inflammation by activating bradykinin B2 receptors. In patients with HAE, they have an absent or dysfunctional C1-esterase inhibitor. This inhibitor is responsible for the production of bradykinin in which displacement of bradykinin from B2 receptors by Firazyr has an inhibitory effect on the receptor for a relatively long time.